Design, formulation and evaluation of nicotine chewing gum

formulation and evaluation of medicated chewing gum of nicotine tartrate

Randomised controlled trial of nicotine chewing-gum.

The effectiveness of 2 mg nicotine chewing-gum as an aid to stopping smoking was compared with a placebo containing 1 mg nicotine, but unbuffered, in a double-blind randomised trial. Of 58 subjects given the active gum, 27 (47%) were not smoking at one-year follow-up compared with 12 (21%) of the 58 subjects treated with placebo (p less than 0.025). By the most stringent criterion of outcome, 1...

Plasma nicotine levels after cigarette smoking and chewing nicotine gum.

Plasma nicotine levels were measured over seven hours of smoking cigarettes (1-2 mg nicotine) in a single subject under standardised conditions, and were compared with the levels obtained from chewing-gum containing either 2 mg or 4 mg nicotine. Levels comparable to those resulting from smoking were not obtained with the 2-mg gum, but peak levels on the 4-mg gum averaged 40-1 ng/ml from the thi...

Formulation of corn zein chewing gum

Ipomoea turpethum R. Br. [= Operculina terpethum (Linn.) Silva Manso (Hindi—Nisoth, Pitohri), a perennial plant with a muchtwisted stem is found through out India. It is reported to be highly medicinal and is cultivated occasionally in gardens as an ornamental plant. Some hydroxy fatty acids, butulin, lupeol and sitosterol have been found in the plant. Seed gums are important vegetable products...

Theoretical background and clinical use of nicotine chewing gum.

In our view, nicotine chewing gum is the most significant single advance achieved so far in the whole field of smoking cessation. It is the only treatment that has yet been shown to have a specific effect over and above that of attention-placebo factors, and this has been demonstrated repeatedly by several research groups in different countries. It is suitable for use as an adjunct both to inte...